Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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Immune thrombocytopenic purpura ITP. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines  and a normal bleeding time does not exclude a platelet disorder. Management of adult idiopathic thrombocytopenic purpura. This website also contains material copyrighted by 3rd parties.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
The clinical presentation may be acute with severe bleeding, or insidious with slow development with trombksitopenia or no symptoms. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. Patient was admitted in Hematology Ward, Government General Hospital, Chennai on and treatment was started as described below: Health Topics A-Z Read more. The incidence of ITP is new cases per million per year, with children accounting for half of that amount and the median age of adults at the diagnosis is The evolution of drug discovery: Assessment of antithrombocyte antibody may assist in establishing the diagnosis of ITP.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
The mechanism of action of anti-D is not fully understood. Patient started treatment 7 years back and was on tablet isosorbide dinitrate 10 mg, tablet tromgositopenia 25 mg, tablet envas 5 mg and patient had discontinued aspirin 6 months back.
Footnotes Source of Support: Signs of chronic disease, infection, wasting, or poor nutrition indicate that the patient has another illness.
Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis. Journal Statistics View My Stats. Patient was also the known case of ischemic heart disease for past 7 years.
The latter examination in ITP shows low numbers of normal-sized platelets, occasionally also giant platelets, while erythrocytes and leukocytes have a normal morphology.
Dapsone also called diphenylsulfone, DDS, or avlosulfon is an anti-infective sulfone drug. In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with trombositopwnia, which is more expensive and less safe. Ninety-six percent of reported ITP-related deaths were individuals 45 years or older.
From Wikipedia, the free encyclopedia. This page was last edited on 27 Septemberat Children should be discouraged from rough contact sports or other activities that increase the risk of trauma.
Abstract Idiopathic thrombocytopenic purpura ITP is defined as a trombositopenla disorder, characterized by trombositopenla thrombocytopenia without a clinically apparent cause. Patients are also advised to avoid using aspirin or ibuprofen as pain relievers because these drugs lengthen the clotting time of blood.
Some children may need treatment. Then, secondary causes 5—10 percent of suspected ITP cases should be excluded. The dose and mode of administration is determined by platelet count and whether there is active bleeding: All medications for ITP are given either orally or IV; intramuscular injection is avoided due to the possibility of adalag bleeding into the skin. Bleeding time is usually prolonged in ITP patients. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region.
Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia
In chronic refractory cases, where immune pathogenesis has been confirmed,  the off-label use of the vinca alkaloid    and chemotherapy agent vincristine may be attempted.
If the disease does not get better with prednisone, other treatments may include: Medicine called danazol Danocrine taken by mouth Infusions of high-dose gamma globulin an immune factor Drugs that suppress the immune system Anti-RhD therapy for people with certain blood types Drugs that stimulate the bone marrow to make more platelets People with ITP should not take aspirin, ibuprofen, or warfarin, because these drugs interfere with platelet function or blood clotting, and bleeding may occur.
The diagnosis of ITP also requires a medical history anamnesisphysical examination, platelet count, and examination of a peripheral blood smear. Recent evidence suggests that the stimulus for autoantibody production in ITP is due to abnormal T helper cells reacting with platelet antigens on the surface of antigen presenting cells. First, one has to make sure that there are no other blood abnormalities except for low platelet count and no physical signs except for signs of bleeding.
Urea breath testing and stool antigen testing perform better than serology -based tests; moreover, serology may be false-positive after treatment with IVIG. ITP symptoms can include any of the following: Immune thrombocytopenic purpura ITP.
Immune thrombocytopenic purpura
Splenectomy removal of the spleen may be considered in patients who are either unresponsive to steroid treatment, have frequent relapses, or cannot be tapered off steroids after a few months. The decision to treat ITP is based on the platelet count, degree of bleeding, and patient’s lifestyle. Initial treatment usually consists of the administration of corticosteroidsa group of medications that suppress the immune system.
Hence one may be considered thrombocytopenic below that range, although the threshold for a diagnosis of ITP is not tied to any specific number.
There is marked variability in the clinical presentation of ITP.