Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

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The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine SAM. Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. The British Journal of Psychiatry.

Catechol-O-methyltransferase – Wikipedia

Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. The best-studied is ValMet. Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator.

However, tolcapone is clinically restricted owning to its increased hepatotoxicity and other related digestive disorders. Journal of Neural Transmission.

COMT inhibition in the treatment of Parkinson’s disease.

In other projects Wikimedia Commons. For tolcapone and mg have most often proved to ce the optimal doses. Entacapone acts mainly peripherally whereas tolcapone acts both peripherally and centrally.


Lay summary — MedWireNews. Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase.

ES2282924T3 – Inhibidores de la comt. – Google Patents

The O in the name stands for oxygennot for ortho. They induce a dose-dependent inhibition of COMT activity in erythrocytes and a significant decrease inhibiores the plasma levels of 3-O-methyldopa, indicating their effectiveness as COMT inhibitors. Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase. Histamine N-methyltransferase Diamine oxidase.

Student consult 7th ed. When given with an inhibitor of dopa decarboxylase carbidopa or benserazidelevodopa is optimally saved. This page was last edited on 21 Novemberat Tyrosine hydroxylase Inhibidpres L-amino acid decarboxylase Dopamine beta-hydroxylase Phenylethanolamine N-methyltransferase.

The Journal of Biological Chemistry. Tryptophan hydroxylase Aromatic L-amino acid decarboxylase Aralkylamine N-acetyltransferase Acetylserotonin O-methyltransferase.

The dyskinesias are managed by decreasing the daily levodopa dose in Parkinson’s disease patients with end-of-dose fluctuations. Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase. Both pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo. This “triple therapy” is becoming a standard in the treatment of Parkinson’s disease.

Catechol- O -methyltransferase is involved in the inactivation of the catecholamine neurotransmitters dopamineepinephrineand norepinephrine. Hydroxymethyltransferase Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. Levodopaa precursor of catecholamines, is an important substrate of COMT.

Views Read Edit View history. Given the preferential role of COMT in prefrontal dopamine degradation, the ValMet polymorphism is thought to exert its effects on cognition by modulating dopamine signaling in the frontal lobes.


In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter DATsuch as the prefrontal cortex.

Thus, COMT inhibitors are clinically significant and beneficial adjunct to levodopa therapy in Parkinson’s disease patients with end-of-dose fluctuations. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.

COMT is the name given to the gene that codes for this enzyme. Molecular and Cellular Biology portal. Genes on human chromosome 22 EC 2. Oroszi G, Goldman D December A functional single-nucleotide polymorphism a common normal variant of the gene for catechol-O-methyltransferase results in a valine to methionine mutation at position Val Met rs EC number Enzyme superfamily Enzyme family List cimt enzymes.